John Barrymore
Dr. Henry Jekyll / Mr. Edward Hyde
Brandon Hurst
Sir George Carewe
Martha Mansfield
Millicent Carewe
Charles Lane
Dr. Richard Lanyon
Cecil Clovelly
Edward Enfield
Nita Naldi
Miss Gina
Louis Wolheim
Music Hall Proprietor
Alma Aiken
Extra (uncredited)
J. Malcolm Dunn
John Utterson (uncredited)
Ferdinand Gottschalk
Old Man at Table in Music Hall (uncredited)
Julia Hurley
Hyde's Landlady with Lamp (uncredited)
Jack McHugh
Street Kid - Raises Fist to Mr. Hyde (uncredited)
Georgie Drew Mendum
Patron in Music Hall (uncredited)
Blanche Ring
Woman at Table with Old Man in Music Hall (uncredited)
May Robson
Prostitute at Clinic (uncredited)
George Stevens
Jekyll's Butler Poole (uncredited)
Edgard Varèse
Policeman (uncredited)